Liverpool conceded a 90th-minute goal at Lyon to leave their Champions League hopes hanging in the balance.
Substitute Ryan Babel had put the Reds ahead late on with a 25-yard thunderbolt into the top corner.
But some sloppy defending allowed Lisandro through on goal and he calmly dinked a shot over Liverpool keeper Pepe Reina to dramatically equalise.
Lyon are now in the last 16 but the Reds are five points behind second-placed Fiorentina with two games to go.
Liverpool have to beat Debrecen and Fiorentina, while hoping other results go their way to stand a chance of reaching the last 16.
The situation should have been a lot more promising for the visitors but they were mainly guilty of wasting a number of chances in a match they dominated against Lyon at the Stade Gerland
Andriy Voronin was the culprit of the most glaring miss, while Fernando Torres, who was nursing a hernia problem, and Lucas Leiva also failed to turn Liverpool's superiority into goals.
It seemed like Babel had grabbed a winner with his late strike but the defensive vulnerability which has dogged Liverpool's season so far struck at the worst possible time to let Lisandro in and break the visitors' hearts
